Clout Stimulates Explosive Muscular Power and Strength. Clout also Supports Endurance and Recovery. At MAN Sports we believe anything is possible. Within this state of mind, incredible innovations are dreamt and brought to reality. Our newest development has shattered old world beliefs, defying existing barriers and obstacles effortlessly, bringing to the market state of the art strength, stamina and recovery supplementation. This work, this Holy-grail, is the end result of the perfected balance of vision, passion, science, innovation and technology. Not only are the ingredients in this supplement completely supported by genuine clinical studies, but this new supplement has also been in the trenches, tested, and tested again by real world athletes. Clout has been reformulated to deliver better taste and even better performance over the much vaunted and heralded original formulation. Once again, Clout delivers 8 powerful, never-before combined bioactives in scientifically proven doses to create a new and exciting direction in supplementation maximizing human performance, body composition and optimizing the athletic environment. Distinguishing itself from existing run-of-the-mill creatine matrix's, the ingredients in Clout are proven by scientific studies to enhance your bodies natural abilities to fight the primary causes of fatigue, enhance recovery, and increase explosive muscular fire power, thereby ushering in the future of muscle augmenting nutrition. By completely redefining the use of creatine MAN Sports welcomes you to the next level! MAN-UP and SEIZE THE POWER with Clout the revolutionary innovative technology that brings you real strength, power, stamina, recovery and growth you can feel. Clout ’s compounds in detail: Bioactives # 1 & 2 Orotine (TriCreatine-Orotate) & Orotic Acid What Is It? Orotine (Tricreatine orotate) complex is a proprietary 3:1 molar ratio of creatine to Orotic Acid. In Clout its inclusion is at a dose to deliver the exact dose of creatine proven to enhance muscle creatine stores. Orotic Acid (OA) is bond to creatine and also supplied to exactly match orotic acid doses in human studies shown to enhance performance. So why do creatine and OA work so well together? And how do they work in synergy? How Does It Work? Declining muscle pH can detrimentally affect muscle function and one possible way to prevent this decline is by enhancing the systems that prevent this fall. Think FIRE EXTINGUISHER. Two central components of these systems are phosphocreatine and carnosine. True to form Clout yet again delivers the exact dose of creatine shown to elevate muscle phosphocreatine levels. Clout also provides the exact level of Orotic Acid shown to work effectively on three levels: Enhancement of performance. This may have been achieved by a selection of Mechanisms but of most importance is as a precursor for carnosine synthesis. In fact research proves that Orotic Acid is very much a nutrient that can increase muscle carnosine levels. Orotic Acid has been shown to increase muscle Uridine levels. Work by Rosenfeldt et al. (1998) showed under hypoxic (lack of oxygen) conditions (found following anaerobic exercise) elevation of intramuscular Uridine levels increased muscle phosphocreatine and creatine levels 38% and 3%, respectively. Elevated Uridine levels, a RNA base, have been shown to increase muscle contractile capacity. Lastly, Orotate salts being neutrally charged pass easily through cell membranes. In effect, orotate shuttles the mineral atoms into cells and tissues, producing higher concentrations. Considering the creatine’s inherent issues with bioavailability and stability bioavailability, orotic acid is advantageous in resolving those issues. OA thus improves creatine’s efficacy and rate of target tissue saturation of phosphocreatine. That's Not All...Orotic Acid Has Been Proven To: Enhance and Maintain ATP pools Increase Glucose Uptake Increase Ribose Moieties (R-1-P & R-5-P) Leading to Enhanced Ribose Formation Increased Muscle Carnosine Stores Support and Enhance Muscle Hypertrophy (via RNA synthesis support during growth) What Evidence For Performance Effect? Golf et al. (1998) carried out a human trial using again the exact dose delivered with Clout. The aim of this study was to assess the effects of Magnesium-Orotate on swim, cycling and run performance. Performance was enhanced with supplementation but backing up the influence of orotate rather than magnesium was the measured lower hydrogen ion levels. This is suggestive of enhanced buffering capacity via orotate by elevated muscle carnosine contents. Therefore, these two ingredients may set off each others functions in many ways. Orotic Acid and creatine both enhance your muscles buffering capacity, literally putting out the fire. As an added bonus orotic acid may help preserve creatine levels during intense hypoxic (lacking oxygen) exercise. Bioactive #4 N-Acetyl Cysteine (NAC) What Is It? Acetyl group donation as mentioned earlier a donor of acetyl groups could radically impact performance by activating the PDH complex. One such acetyl donating nutrient is the antioxidant N-Acetyl cysteine. However, the great effects of NAC don't stop at delivering acetyl groups. How Does It Work? N-Acetyl Cysteine again is a powerful antioxidant and its main influence on muscle damaging free radicals is its influence at enhancing muscle and other cell glutathione levels. Secondly, it can also provide acetyl groups which could be used for entry into the Krebs cycle and energy generation overcoming deficiencies in the PDH complex. What Evidence For Performance Effect? There are two immense supplementation studies that show the influence of cysteine donors on performance. Sen et al. (1994) gave 200 x 4mg/day of NAC and an 800mg bolus before a maximal bike test. Clout delivers probably the highest amounts of NAC in any sports supplement many times above the cysteine and acetyl groups delivered in these studies! OK back to the outcome of the Sen study, NAC resulted in a higher net post exercise antioxidant capacity. But can elevating oxidative capacity through cysteine donation influence performance? The answer is simply YES! A study presented at the ACSM on whey protein delivering similar cysteine levels to those in Clout improved muscle fatigue during fatiguing leg extension exercise. Bioactive #5 Inositol HexaPhosphate (IP6) What Is It? IP6 is simply inositol hexaphosphate where 6 phosphate groups are bound to a 6 carbon skeleton (the backbone in organic chem.). IP6 is a novel phosphate donor, which reduces the GI distress of traditional mineral phosphate loading. This compound is being studied for its anti-carcinogenic effects and further promoted by longevity researchers. As far as IP6 is concerned, research has shown that IP6 a compound ingested is actually IP3 as the bio-active (and what's in the cell) with the anti-carcinogenic effects. This means 3 phosphates are 'freed' and hence donated. Phosphate 'donation' would theoretically lead to enhanced athletic performance as mentioned below. IP6 is one of those exciting compounds if you read on the longevity sites and far more beneficial than just as an ergogenic. AMP (adenosine monophosphate) in the mitochondria of the cell requires one more phosphate to make ADP, and yet another to produce ATP. ATP is your basic energy molecule and perhaps the most essential in the idea of ergogenics and athletic performance. Phosphate maybe one of, if not the most important mineral constituent required for cellular activity due to its biological interactions with metabolic intermediates and energy producing compounds. Changes in cellular phosphate levels have been linked to enhanced exercise capacity time and time again. Supplementation is a proven method to achieve this guaranteed performance effect. How Does It Work? There are many possible Mechanisms proposed for the proven influence of phosphate including: Phosphate-stimulated glycolysis (enhanced energy production capacity) Increased red blood cell 2,3-DPG levels (Enhancing oxygen delivery to working muscles) Enhanced creatine phosphate synthesis (increased creatine stores). Therefore, it is easy to see how phosphate addition can further extend the influence of Clout as the ultimate creatine and performance enhancer. What Evidence For Performance Effect? There are many studies proving the performance enhancement of phosphate loading for athletes. Kreider et al. (1992) assessed the influence of 1000mg of phosphate 4 times a day for 3 days or a maltodextrin placebo. The results backed many other studies and showed that phosphate loading could enhance maximal exercise performance (40km time trial). Bioactive #6 Vinpocetine What Is It? Vinpocetine is an extract from lesser periwinkle plant (Vinca Minor). Because we know exercise performance is related to our ability to generate ATP and deliver oxygen the possible enhancing influence of Vinpocetine on these energy-generating systems made its inclusion in Clout essential! How Does It Work? Vinpocetine has been shown to be effective by increasing 2,3 DPG levels (Oxygen delivery capacity), ATP (energy levels), and antioxidant activity. What Evidence For Performance Effect? The effects on exercise performance of Vinpocetine at this point do not exist. What dose exists for the effects in human studies looking at enhancing chemicals that we know can elevate performance capacity. In a study by Tohgi et al. subjects were given 15mg of Vinpocetine per day (a dose lower than that contained in Clout) for 3 weeks. By the end of the supplementation period there were huge increases in cellular ATP as well as an increase in 2, 3 DPG. Bioactive #7 Magnesium Orotate What Is It? As we described at the beginning of this article magnesium is inextricably linked to countless cellular functions. As such the importance of magnesium as a performance enhance cannot be denied. It has been research for several decades now with postoperative cardiac surgery patients with phenomenal success in the form of magnesium orotate, which is also called magnerot. Magnesium plays a number of roles in the body, being required for more than 325 enzymatic reactions, including those involved in the synthesis of muscle protein, as well as muscular contraction and relaxation (including the heart). The synthesis of ATP depletes magnesium-dependent enzymes, known as ATPases. Further, a large-scale survey of athletes in one study were significantly deficient in magnesium, at only 70% of RDA on average. The RDA, does not even represent optimal nutrient intakes for performance athletes/bodybuilders, meaning they may have only been getting half as much as they needed. How Does It Work? Clearly, the safety and efficacy is apparent in that it is used in hundreds of studies and often with a critically fragile population. Further, this is human data…not rats…not extrapolated interpretations of some “similar compound”. So many compounds being released by the supplement industry may be unsafe or lack efficacy where there is no relevant study data published at all. Magnesium-Orotate pushes the performance enhancing potential of Clout through the roof! What Evidence For Performance Effect? In a recent study on magnesium restriction with athletes over 3 months the results were dramatic. For a given workload, peak oxygen uptake, total and cumulative net oxygen utilization and heart rate all were significantly increased during the study period. The amount of the increase direct correlation to the degree of magnesium depletion. These results show in dramatic form the impact of deficiency of this crucial mineral on performance. Bioactive #8 Acetyl L-Carnitine HCL (ALCAR) What Is It? To quote the Physician’s Desk Reference (PDR): “Supplemental acetyl-L-carnitine may have neuroprotective activity. In addition, it, like L-carnitine, may have cardioprotective activity and may beneficially affect cardiac function. It may enhance sperm motiliy. Acetyl-L-carnitine may also have cytoprotective, antioxidant and anti-apoptotic activity.” How Does It Work? ALCAR has a more a rapid and efficacious nootropic effect over standard carnitine because it crosses the blood-brain barrier better. The improved mental performance (nootropic) effect of acetyl L-carnitine often is seen with mood enhancement or well-being. ALCAR and carnitine have numerous important roles in humans. These nutrients shuttle both acetyl groups and fatty acids into mitochondria for energy production, thereby yielding an ergogenic effect. With the absence of carnitine, fatty acids cannot easily enter into mitochondria. What Evidence for Performance Effect? The acetyl group of acetyl L-carnitine is used to form acetyl-CoA, the primary intermediary in the production of energy from amino acids, fats, and carbohydrates. Therefore, acetyl L-carnitine acts as an energy reserve of acetyl groups and both acetylcarnitine and carnitine help enhance ergogenesis for the athlete. The acetyl group of acetyl L-carnitine is also used to make the critical neurotransmitter, acetylcholine. Research also shows that ALCAR may act as a neurotransmitter itself. Supplement Facts: Serving Size: 1 Scoop (12g) Servings Per Container: 50 Amount Per Serving: Orotine (Creatine Orotate; 3:1 molar ratio of Creatine & Orotic Acid) - 3,000mg Beta-Alanine - 1,600mg Acetyl L-Carnitine HCL - 1,500mg Inositol HexaPhosphate (IP6) - 1,000 mg Orotic Acid - 500mg N-Acetyl-Cysteine - 500mg Magnesium Orotate - 500mg Vinpocetine - 8mg Other Ingredients: Corn and Maize Starch, Maltodextrin, Silicon Dioxide, Xanathan gum. Natural and Artificial flavors, Red#40, and sucralose. Directions: To optimize uptake and absorption of Clout take one serving twice daily, one 30 minutes prior to workout and one with food separated by at least a 4-5 hour period. Following this routine for 28 days will optimize concentrations of the ingredients in Clout in muscle tissues. Noticeable effects should be experienced within the first 3 days of use with 80% of total effectiveness achievable by day 12-14 and total effects at 28 days and longer. Clout can be combined with Body Octane and Scorch. Warning: When using with High Voltage Body Octane be aware of Beta-Alanine content in both products. When using Clout with High Voltage Body Octane begin use of each product at half serving 4 times daily as opposed to one full serving of each product twice daily in order to develop a tolerance to Beta-Alanine. Beta-Alanine has the propensity to increase paresthesia (tingling sensation similar to niacin flush). This effect subsides after several days of continuous administration and is an inherent characteristic of Beta-Alanine. Searchables: Clout, cluot, mansports, man sports, lean muscle, strength, power, recovery, muscle gain, muscle mass. You can verify the amount of your Clout purchase in your national currency with the Currency Converter under the image If you have any questions or issues, please contact Americanlifestyle via e-mail or by phone.